Alanine substitutions of phosphor acceptor sites T51, T53 (equivalent to human T69, T71). Transcription factor (BZIP-type, AP1-family)
| Inventor | Institute |
|---|---|
| Nic Jones | Cancer Research UK, Manchester Institute |
| SKU: | 151648 |
|---|---|
| Product description: | Alanine substitutions of phosphor acceptor sites T51, T53 (equivalent to human T69, T71). Transcription factor (BZIP-type, AP1-family) |
| Conditional: | No |
| Genetic background: | Atf2 genomic sequences were isolated by screening a 129/ola mouse cosmid library (RZPD), cloned into pPGKneobpAlox2PGKDTA, transfected into 129/ola embryonic stem cells. Transgenic animals were produced by blastocyst injection and offspring mice were backcrossed at least six times with C57 Bl/6 mice to produce isogenic lines. |
| Production details: | Atf2 genomic sequences were isolated by screening a 129/ola mouse cosmid library (RZPD), cloned into pPGKneobpAlox2PGKDTA, transfected into 129/ola embryonic stem cells. Transgenic animals were produced by blastocyst injection and offspring mice were backcrossed at least six times with C57 Bl/6 mice to produce isogenic lines. |
| Cat. #: | 151648 |
|---|---|
| Research Fields: | Cell biology; Cell signaling and signal transduction; Developmental biology; Genetics; Immunology |
| Target: | ATF2 |
| Zygosity: | Heterozygous |
| Phenotype: | Homozygous postnatal lethality, heterozygous normal phenotype |
| Shipping conditions: | Embryo/Spermatoza- Dry Ice |
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| References: |
Breitwieser et al. 2007. Genes Dev. 21(16):2069-82. PMID: 17699753. Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. |
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