Tamoxifen-resistant MCF7 Breast Cancer cell line

This provides a cell-based model , both in vitro and in vivo, for tam-resistant breast cancer, allows the testing of alternate therapies to tam-resistant breast cancer, or the high-throughput testing of drugs that might synergize with hormone based therapies.

Contributors

Inventor Institute
Saraswati Sukumar Johns Hopkins University
SKU: 156418
Product description: MCF7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. This provides a cell-based model , both in vitro and in vivo, for tam-resistant breast cancer, allows the testing of alternate therapies to tam-resistant breast cancer, or the high-throughput testing of drugs that might synergize with hormone based therapies.
Cellosaurus ID: CVCL_EG55
Disease: Cancer
Cat. #: 156418
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Breast cancer
Research Fields: Cancer; Drug development
Model: Cancer Model
Cancer Types In Detail: Breast cancer
Format: Frozen
Shipping conditions: Dry ice
References:

Wu et al. 2015. Mol Cell Proteomics. 14(11):2887-900. PMID: 26330541.

Related Tools for Cell lines

Cat. # Tool Name
151447 CMT 64 Cell Line Key Info View Tool
151450 JIM3 Cell Line Key Info View Tool
151558 MEF Trex1 KO Cell Line Key Info View Tool
151626 A375P beta6-puro Cell Line Key Info View Tool
151425 TR146 Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.