This cell line over-expresses endogenous Trh4 and provides a key tool to help understand presentation of Trh4 to antigen recognition though other pathways.
| Inventor | Institute |
|---|---|
| Thorbald Van Hall | Leiden University and Leiden University Medical Center; Stichting Oncode Institute |
| SKU: | 157676 |
|---|---|
| Product description: | This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA cells have their TAP chain intact and the Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line over-expresses endogenous Trh4 and provides a key tool to help understand presentation of Trh4 to antigen recognition though other pathways. |
| Cellosaurus ID: | CVCL_J385 |
| Parental cell line: | RMA |
| Disease: | Cancer |
| Cat. #: | 157676 |
|---|---|
| Tool sub type: | Continuous |
| Unit size: | 1×10^6 cells / vial |
| Cancer types: | Blood cancer |
| Research Fields: | Cancer |
| Organism: | Mouse |
| Tissue: | Lymphatic Tissue |
| Model: | Tumour line |
| Cancer Types In Detail: | Mouse Leukemia |
| Format: | Frozen |
|---|---|
| Storage conditions: | Liquid Nitrogen |
| Shipping conditions: | Dry ice |
| Growth medium: | Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct |
| Recommended controls: | RMA-S.Trh4 cells |
| Mycoplasma free: | Yes |
| Biosafety level: | 1 |
| References: |
Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382. |
|---|
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.