RMA.Trh4 cell line

This cell line over-expresses endogenous Trh4 and provides a key tool to help understand presentation of Trh4 to antigen recognition though other pathways.

Contributors

Inventor Institute
Thorbald Van Hall Leiden University and Leiden University Medical Center; Stichting Oncode Institute
Cat. #: 157676
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Blood cancer
Research Fields: Cancer
Organism: Mouse
Tissue: Lymphatic Tissue
Model: Tumour line
Cancer Types In Detail: Mouse Leukemia
Product description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. RMA cells have their TAP chain intact and the Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line over-expresses endogenous Trh4 and provides a key tool to help understand presentation of Trh4 to antigen recognition though other pathways.
Cellosaurus ID: CVCL_J385
Parental cell line: RMA
Disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
Recommended controls: RMA-S.Trh4 cells
Mycoplasma free: Yes
Biosafety level: 1
References:

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.

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