P815.Trh4 cell line

This cell line provides a model to help to understand T-cell recognition through Trh4 expression.

Contributors

Inventor Institute
Thorbald Van Hall Leiden University and Leiden University Medical Center; Stichting Oncode Institute
Cat. #: 157674
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cancer
Organism: Mouse
Tissue: Bone Marrow
Model: Tumour line
Cancer Types In Detail: Mouse mast cell neoplasm
Product description: This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo-antigen selectively presented by cells through various pathways. The P815 cell line has been made to over-express Trh4 and can be utilised to understand this peptide presentation process.
Production details: Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
Cellosaurus ID: CVCL_2154
Parental cell line: P815
Disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Mycoplasma free: Yes
Biosafety level: 1
References:

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.

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