Cells derived from a female mouse with cutaneous squamous cell carcinoma (SCC) lacking osteopontin (OPN) gene. Cells contain p53 and H-ras mutations
| Inventor | Institute |
|---|---|
| Pi-Ling Chang and Yu-Hua Hsieh | The UAB Research Foundation |
| SKU: | 161802 |
|---|---|
| Product description: | Cells derived from a female mouse with cutaneous squamous cell carcinoma (SCC) lacking osteopontin (OPN) gene. Cells contain p53 and H-ras mutations which are common characteristics of SCCs. These cells develop SCC in syngeneic wild-type and OPN-null mice. Cell line is great for studying host-derived OPN at the systemic and tumor microenvironmnet level in the context of extrinsic cancer cell progression in immune-competent mice |
| Gender: | Female |
| CRISPR: | No |
| Production details: | OPN-null and WT mice in 129S6/SvEv background were bred in-house. ONSC cells were derived from an SCC developed in a female OPN-null mouse subjected to two-stage skin carcinogenesis. Cells were maintained in high-glucose, low-calcium DMEM containing 10% fetal bovine serum. |
| Receptors of note: | No |
| Cat. #: | 161802 |
|---|---|
| Cancer types: | Skin cancer |
| Research Fields: | Cancer |
| Organism: | Mouse |
| Tissue: | Skin |
| Gender: | Female |
| Growth properties: | Adherent |
| Primary citation: | Hsieh et.al. 2012. Int J Cancer. PMID: 21826648 |
| Growth medium: | DMEM with 10% fetal bovine serum |
|---|
| References: |
Hsieh et.al. 2012. Int J Cancer. PMID: 21826648 |
|---|
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.