NUCOLL43 Cell Line

Ovarian cancer is a significant cause of death in women worldwide with the majority of ovarian cancers forming in women under the age of 65. Due to late stage diagnosis and a lack of reliable screening tests, survival rates after 5 years are below 50% in developing counties. Ovarian cancer can spread to tissues in […]

Contributors

Inventor Institute
Nicola Curtin Northern Institute For Cancer Research, Newcastle University
Cat. #: 153716
Tool sub type: Primary
Unit size: 1×10^6 cells / vial
Cancer types: Ovarian cancer
Research Fields: Cancer;Cell biology;Genetics
Organism: Human
Tissue: Ovary
Gender: Female
Model: Cancer Model
Growth properties: Doubling time approximately 45 hours
Cancer Types In Detail: Ovarian clear cell carcinoma
Alternate name: O-CCC, ovarian clear cell carcinoma, HGSC, high grade ovarian cancer, TP53, CA125, LOH, loss of heterozygosity
Product description: Ovarian cancer is a significant cause of death in women worldwide with the majority of ovarian cancers forming in women under the age of 65. Due to late stage diagnosis and a lack of reliable screening tests, survival rates after 5 years are below 50% in developing counties. Ovarian cancer can spread to tissues in close proximity to the ovaries, including the lining of the abdomen, lungs, lymph nodes and liver. Ovarian cancer has a number of histological subtypes and ovarian clear cell carcinomas generally respond poorly to chemotherapy. NUCOLL43 was established from ascitic fluid from a female 57 year old white British patient without artifical immortalisation. Cells display a complete loss of TP53 expression and function despite having no loss of chromosome 17p and show highly similar pan-genomic similarity to the original patient tumor. Like the original tumor, the cells also expressed epithelial and mesenchymal characteristics. NUCOLL43 cells poses a very high degree of loss of heterozygosity which affected 85% of the genome.NUCOLL43 cells are resistant to cisplatin and rucaparib, but sensitive to paclitaxel, camptothecin and NVP-BEZ 235.
Gender: Female
Conditional: No
Parental cell line: Clear cell adenocarcinoma of gynecological origin
Disease: Cancer
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: RPMI-1640 media supplemented with 20% FBS and cultured at 37?‚°C in 5% CO2.
Mycoplasma free: Yes
Biosafety level: 1
References:

Franklin et al. 2018. Cancer Med. :. PMID: 30109783.

Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor.

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