| Inventor | Institute |
|---|---|
| Nicola Curtin | Northern Institute For Cancer Research, Newcastle University |
| SKU: | 153716 |
|---|---|
| Product description: | Ovarian cancer is a significant cause of death in women worldwide with the majority of ovarian cancers forming in women under the age of 65. Due to late stage diagnosis and a lack of reliable screening tests, survival rates after 5 years are below 50% in developing counties. Ovarian cancer can spread to tissues in close proximity to the ovaries, including the lining of the abdomen, lungs, lymph nodes and liver. Ovarian cancer has a number of histological subtypes and ovarian clear cell carcinomas generally respond poorly to chemotherapy. NUCOLL43 was established from ascitic fluid from a female 57 year old white British patient without artifical immortalisation. Cells display a complete loss of TP53 expression and function despite having no loss of chromosome 17p and show highly similar pan-genomic similarity to the original patient tumor. Like the original tumor, the cells also expressed epithelial and mesenchymal characteristics. NUCOLL43 cells poses a very high degree of loss of heterozygosity which affected 85% of the genome.NUCOLL43 cells are resistant to cisplatin and rucaparib, but sensitive to paclitaxel, camptothecin and NVP-BEZ 235. |
| Alternate name: | O-CCC, ovarian clear cell carcinoma, HGSC, high grade ovarian cancer, TP53, CA125, LOH, loss of heterozygosity |
| Gender: | Female |
| Conditional: | No |
| Parental cell line: | Clear cell adenocarcinoma of gynecological origin |
| Disease: | Cancer |
| Cat. #: | 153716 |
|---|---|
| Tool sub type: | Primary |
| Unit size: | 1×10^6 cells / vial |
| Cancer types: | Ovarian cancer |
| Organism: | Human |
| Tissue: | Ovary |
| Gender: | Female |
| Model: | Cancer Model |
| Growth properties: | Doubling time approximately 45 hours |
| Cancer Types In Detail: | Ovarian clear cell carcinoma |
| Format: | Frozen |
|---|---|
| Storage conditions: | Liquid Nitrogen |
| Shipping conditions: | Dry ice |
| Growth medium: | RPMI-1640 media supplemented with 20% FBS and cultured at 37?°C in 5% CO2. |
| Mycoplasma free: | Yes |
| Biosafety level: | 1 |
| References: |
Franklin et al. 2018. Cancer Med. :. PMID: 30109783. Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor. |
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