Mutant DISC1 cell line

To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant…

Contributors

Inventor Institute
Mikhail Plentnikov Johns Hopkins University
SKU: 156416
Product description: To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses.
Parental cell line: PC12
Disease: Schizophrenia
Cat. #: 156416
Unit size: 1×10^6 cells / vial
Research Fields: Drug development;Neurobiology
Format: Frozen
Shipping conditions: Dry ice

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