melan-Ink4a-Arf2 is an immortal melanocyte cell line from the skin of neonatal Ink4a-Arf–/– C57BL/6J mice
| Inventor | Institute |
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| Elena Sviderskaya | St. George's University London |
| SKU: | 161993 |
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| Product description: | The melan-Ink4a-Arf1, -2, -3 and -4 are immortalised mouse melanocyte lines derived from the skin of neonatal Ink4a-Arf–/– C57BL/6J mice. Each line was derived independently from a different littermate of the same background. These cells are visibly pigmented and display morphology typical of normal melanocytes. The INK4A-ARF locus encodes two inhibitors of cellular growth (p16INK4A and ARF) and is often mutated in a range of human cancers including melanoma. Therefore, these melanocytes can be used as a model of normal skin melanocytes in studies focussing on skin cancers and melanomas. They are also a useful tool for studies of pigmentation genetics and as a control for numerous other lines in the collection, as many of these have also been derived from mice that are null for Ink4a-Arf. |
| Cat. #: | 161993 |
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| Organism: | Mouse |
| Tissue: | Skin |
| Model: | Immortalised non-cancerous cell lines |
| Morphology: | Small, oval-fusiform |
| Primary citation: | Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20;94(6):446-54. PMID: 11904317 |
| Storage conditions: | liquid N2 |
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| Growth medium: | RPMI + FBS (10%) + TPA (200 nM) + cholera toxin (CT) (200 pM) |
| References: |
Sviderskaya EV, et al. J Natl Cancer Inst. 2002 Mar 20 94(6):446-54. PMID: 11904317 |
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