HT-29 is a widely used human colorectal adenocarcinoma cell line, exhibiting sensitivity to chemotherapeutic agents such as 5-fluorouracil (5FU) and oxaliplatin. These cells display phenotypic characteristics of mature intestinal cells, including enterocytes, making them a well-established in vitro model for studying food digestion and bioavailability. Additionally, HT-29 cells are used in drug discovery and microbiological research to investigate probiotics and bacteriophage therapies.
Alternate name:
HT29; HT 29
Gender:
Female
Disease:
Adenocarcinoma; Colorectal Cancer
Products or characteristics of interest:
Karyotype: hypertriploid, modal number = 71; range = 68 to 72. Isoenzymes: AK-1, 1; ES-D, 1-2; G6PD, B; GLO-I, 2; PGM1, 1-2; PGM3, 2
Cat. #:
161929
Cancer types:
Colorectal cancer
Tissue:
Colon tissue
Gender:
Female
Morphology:
Epithelial
Growth properties:
Adherent
Primary citation:
Fogh et al. 1977. Journal of the National Cancer Institute. 59.1.221. PMID: 327080.
Shipping conditions:
Dry Ice
Growth medium:
McCoy’s 5a Medium Modified with fetal bovine serum to a final concentration of 10%.
Temperature:
37° C
Atmosphere:
5% CO2 in air
Storage medium:
Complete growth medium supplemented with 5% DMSO
Biosafety level:
1
References:
Nautiyal et al. 2011. Journal of molecular signaling. 6:7. PMID: 21774804.
Cohen et al. 1999. Journal of cell science. 112.16.2657. PMID: 10413674.
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