ADAM10 is a <U+0091>molecular scissor<U+0092> that proteolytically cleaves the extracellular region from over 100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors and chemokines.
| Inventor | Institute |
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| Michael Tomlinson | University of Birmingham |
| SKU: | 157701 |
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| Product description: | A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer?Âs and inflammatory diseases. ADAM10 is a ?Âmolecular scissor? that proteolytically cleaves the extracellular region from over 100 substrates, including Notch, amyloid precursor protein, cadherins, growth factors and chemokines.CRISPR edited ADAM 10 HEK-293T cells.Generation of CRISPR/Cas9-knockout cell line:A guide RNA sequences was selected for human ADAM10, and the following primer pairs were used to encode these sequences: ADAM10 guide 2 (5?Â-CACCGATACCTCTCATATTTACAC-3? and 5?Â-AAACGTGTAAATATGAGAGGTATC-3?Â) |
| Alternate name: | A Disintegrin And Metalloproteinase domain-containing protein 1, CRISPR-Cas9 |
| Parental cell line: | HEK 293T |
| Disease: | Cancer |
| Cat. #: | 157701 |
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| Tool sub type: | Continuous |
| Unit size: | 1×10^6 cells / vial |
| Research Fields: | Cancer;Neurobiology |
| Organism: | Human |
| Tissue: | Kidney |
| Format: | Frozen |
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| Shipping conditions: | Dry ice |
| Growth medium: | Cancer Research Technology Limited (trading research tools as Ximbio) has been granted a non-exclusive license to the CRISPR-Cas9 technology by ERS Genomics Ltd under the patent rights listed here.This license from ERS Genomics Ltd allows Ximbio to develop and commercialise CRISPR-Cas9 modified cell lines for research use only. Ximbio can provide these modified CRISPR-Cas9 … |
| References: |
Tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex Brummer et al. 2018. FASEB J. 32(7):3560-3573. PMID: 29430990. |
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