HCT 116-I6 Invasive Cell Line

The HCT 116-I6 cell line is a sub-line of HCT 116 that demonstrates a 4- and 20-fold increase in migration and invasion rate respectively compared to the parental cell line.

Contributors

Inventor Institute
Sandra Van Schaeybroeck Queen's University Belfast
SKU: 153208
Product description: The HCT 116-I6 cell line is a sub-line of HCT 116 that demonstrates a 4- and 20-fold increase in migration and invasion rate respectively compared to the parental cell line.
Conditional: No
Production details: HCT 116 cells were incubated in a Matrigel Invasion Chambers (MIC) for 72-96h. The cells that invaded through to the bottom chamber were collected and designated as â?‚€?‚˜Invasive 1â?‚€?‚™ (I1). These cells were propagated and repeatedly passed through the MIC until highly invasive HCT116-I6 cells were selected.
Cellosaurus ID: CVCL_HG06
Parental cell line: HCT 116
Disease: Cancer
Cat. #: 153208
Provenance and Ownership: The HCT 116-I6 Invasive Cell Line is owned by Cancer Research UK. CancerTools supplies the HCT 116-I6 Invasive Cell Line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing HCT 116-I6 Invasive Cell Line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Cancer types: Colorectal cancer
Research Fields: Cancer; Cell biology; Drug development
Organism: Human
Tissue: Colon
Model: Cancer Model
Growth properties: Invasion, migration
Cancer Types In Detail: Colorectal
Format: Frozen
Shipping conditions: Dry ice
Growth medium: McCoy’s 5a Medium (GIBCO # 16600) + 10% FBS + 100 units/ml penicillin+ 100 ?g/ml streptomycin
References:

Dunne et al. 2016. Clin Cancer Res. 22(1):230-42. PMID: 26283684.

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.

Dunne et al. 2014. Clin Cancer Res. 20(1):164-75. PMID: 24170546.

AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.

Related Tools for Cell lines

Cat. # Tool Name
151559 MEF UNG KO Cell Line Key Info View Tool
151446 FLYRD18 Cell Line Key Info View Tool
151449 JIM1 Cell Line Key Info View Tool
151629 MEF Raf1 FF/FF KI Cell Line Key Info View Tool
151655 FLYA-13 Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.