EML4‑ALK mutant murine lung cancer cell line

Syngeneic murine lung cancer cell line with EML4-ALK gene fusion for use in immunocompetent orthotopic models.

SKU: 162389
Product description: A novel syngeneic EML4‑ALK mutant murine lung cancer cell line (Y143) with orthotopic growth potential, that can serve as a useful preclinical model for evaluating tumour-host interactions, the impact of specific oncogenic alterations on the tumor microenvironment, and immunotherapeutic approaches. This cell line was derived from the primary lung tumour of a female C57BL/6 mouse harbouring the EML4-ELK gene fusion and is capable of forming orthotopic tumours in immunocompetent C57BL/6 mice. Y143 cells demonstrate the EML4-ALK genetic rearrangement as shown by PCR. In Y143 cells treatment with the EML4-ALK inhibitor crizotinib inhibits phosphorylation of AKT and ERK is inhibited in a dose dependent manner and treatment with the ALK kinase inhibitor, TAE684, inhibits growth of Y143 cells.
Cat. #: 162389
Cancer types: Lung cancer

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Hematoxylin and eosin stain showing orthotopic lung tumor formation by the EML4‑ALK mutant (Y143) murine lung cancer cell line

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