Caov-3 Cell Line

The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour […]

Contributors

Inventor Institute
Jorgen Fogh Memorial Sloan-Kettering Cancer Center (MSK)
Cat. #: 161926
Cancer types: Ovarian cancer
Organism: Human
Tissue: Ovary
Gender: Female
Morphology: Epithelial
Growth properties: Adherent
Primary citation: Buick et al. 1985. Cancer Research. 45: 3668-3676. PMID: 4016745.
Product description: The Caov-3 cell line is a primary ovarian cancer cell line with epithelial morphology. These cells form tightly packed colonies in adherent culture. All-trans retinoic acid has been shown to suppress the growth of Caov-3 ovarian carcinoma cells in vitro. These cells express the NB/70K, CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive to vinblastine, cisplatin, and adriamycin. These cells fail to grow in soft agar but are tumourigenic when injected into immunocompromised mice.
Gender: Female
Products or characteristics of interest: Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 2; PGM1, 1; PGM3, 1
Storage conditions: Vapor phase of liquid nitrogen
Shipping conditions: Dry Ice
Growth medium: EMEM supplemented with FBS to a final concentration of 10%
Temperature: 37° C
Atmosphere: 5% CO2 in air
Storage medium: Complete growth medium supplemented with 5% (v/v) DMSO
Biosafety level: 1
References:

Yaginuma et al. 1992. Cancer Research. 52: 4196-4199. PMID: 1638534.

Shayesteh et al. 1999. Nature Genetics. 21: 99-102. PMID: 9916799.

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