| Inventor | Institute |
|---|---|
| Jorgen Fogh, Germain Trempe | Memorial Sloan-Kettering Cancer Center (MSK) |
| SKU: | 161904 |
|---|---|
| Product description: | Human Renal Cancer Cell Line. Caki-2 is a human clear cell renal cell carcinoma (ccRCC) line that displays epithelial morphology and grows in adherent culture. These cells are a useful preclinical model to study renal cancer. They are relatively less sensitive to 5-fluorouracil and sorafenib (multi-kinase inhibitor of VEGFRs 1-3, PDGFR-b, and Raf-1) compared to Caki-1 cells. The Caki-2 cells have a loss-of-function mutation in the von Hippel-Lindau (VHL) tumour-suppressor protein and are known to form tumours in immunocompromised mice. |
| Gender: | Male |
| Products or characteristics of interest: | Karyotype: hypopentaploid to hypohexaploid (+A2, +A3, +B, +C, +D, +F, +G, -A) with abnormalities including dicentrics, acrocentric fragments, minutes, breaks, and large subtelocentric markers. Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 1; PGM1, 1; PGM3, 1 |
| Cat. #: | 161904 |
|---|---|
| Cancer types: | Renal cancer |
| Organism: | Human |
| Tissue: | Kidney |
| Gender: | Male |
| Morphology: | Epithelial |
| Growth properties: | Adherent |
| Cancer Types In Detail: | Clear cell carcinoma |
| Primary citation: | Fogh J et al. 1977. Journal of the National Cancer Institute. 59: 221-226. PMID: 327080. |
| Shipping conditions: | Dry Ice |
|---|---|
| Growth medium: | McCoy’s 5a Medium Modified supplemented with 10% FBS |
| Temperature: | 37° C |
| Storage medium: | Complete growth medium supplemented with 5% (v/v) DMSO |
| Biosafety level: | 1 |
| References: |
Fogh J et al. 1977. Journal of the National Cancer Institute 59: 221-226. PMID: 327080. Miyake M et al. 2012. Oncology Letters. 3: 1195-1202. PMID: 22783417. |
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