Caki-2 Cell line

Human Renal Cancer Cell Line. Caki-2 is a human clear cell renal cell carcinoma (ccRCC) line that displays epithelial morphology and grows in adherent culture. These cells are a useful preclinical model to study renal cancer. They are relatively less sensitive to 5-fluorouracil and sorafenib (multi-kinase inhibitor of VEGFRs 1-3, PDGFR-b, and Raf-1) compared to […]

Contributors

Inventor Institute
Jorgen Fogh, Germain Trempe Memorial Sloan-Kettering Cancer Center (MSK)
Cat. #: 161904
Cancer types: Renal cancer
Organism: Human
Tissue: Kidney
Gender: Male
Morphology: Epithelial
Growth properties: Adherent
Cancer Types In Detail: Clear cell carcinoma
Primary citation: Fogh J et al. 1977. Journal of the National Cancer Institute. 59: 221-226. PMID: 327080.
Product description: Human Renal Cancer Cell Line. Caki-2 is a human clear cell renal cell carcinoma (ccRCC) line that displays epithelial morphology and grows in adherent culture. These cells are a useful preclinical model to study renal cancer. They are relatively less sensitive to 5-fluorouracil and sorafenib (multi-kinase inhibitor of VEGFRs 1-3, PDGFR-b, and Raf-1) compared to Caki-1 cells. The Caki-2 cells have a loss-of-function mutation in the von Hippel-Lindau (VHL) tumour-suppressor protein and are known to form tumours in immunocompromised mice.
Gender: Male
Products or characteristics of interest: Karyotype: hypopentaploid to hypohexaploid (+A2, +A3, +B, +C, +D, +F, +G, -A) with abnormalities including dicentrics, acrocentric fragments, minutes, breaks, and large subtelocentric markers. Isoenzymes: AK-1, 1; ES-D, 1; G6PD, B; GLO-I, 1-2; Me-2, 1; PGM1, 1; PGM3, 1
Shipping conditions: Dry Ice
Growth medium: McCoy's 5a Medium Modified supplemented with 10% FBS
Temperature: 37° C
Storage medium: Complete growth medium supplemented with 5% (v/v) DMSO
Biosafety level: 1
References:

Fogh J et al. 1977. Journal of the National Cancer Institute 59: 221-226. PMID: 327080.

Miyake M et al. 2012. Oncology Letters. 3: 1195-1202. PMID: 22783417.

Related Tools for Cell lines

Cat. # Tool Name
151484 2fTGH Cell Line Key Info View Tool
151629 MEF Raf1 FF/FF KI Cell Line Key Info View Tool
151665 MEF PKCe KO Cell Line Key Info View Tool
151558 MEF Trex1 KO Cell Line Key Info View Tool
151576 MEF RAF1 KO Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.