786-O cell line knockout for PBRM1 (clone 2, also called clone 2.7)
| Inventor | Institute |
|---|---|
| Jessica Downs, Karen Lane | The Institute of Cancer Research |
| SKU: | 161885 |
|---|---|
| Product description: | 786-O cell line knockout for PBRM1 (clone 2, also called clone 2.7). This cell line was generated using CRISPR-Cas9 engineering to create a loss of function mutation in the indicated subunit of the SWI/SNF chromatin remodelling complex. The cell line was validated using Sanger sequencing, immunofluorescence, and proteomic analysis. |
| Gender: | Male |
| CRISPR: | Yes |
| Conditional: | No |
| Cellosaurus ID: | CVCL_1051 |
| Parental cell line: | 786-O |
| Model description: | PBRM1 knockout |
| Products or characteristics of interest: | Gene loss-of-function, chromatin-remodelling, DNA damage, cell cycle response, regulation of t-cell-mediated cell killing. |
| Cat. #: | 161885 |
|---|---|
| Cancer types: | Renal cancer |
| Research Fields: | Cancer |
| Organism: | Human |
| Tissue: | kidney |
| Gender: | Male |
| Model: | Genetically modified |
| Morphology: | Epithelial |
| Growth properties: | Adherent |
| Format: | Frozen |
|---|---|
| Storage conditions: | Liquid Nitrogen |
| Shipping conditions: | Dry ice |
| Growth medium: | RPMI-1640+ 10S + 1% Penicillin/Streptomycin |
| Temperature: | 37C |
| Atmosphere: | 5% CO2 in air |
| Biosafety level: | 1 |
| References: |
Unpublished |
|---|
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