2C4 cell line

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The 2C4 cell line is a clonal derivative of the human fibrosarcoma cell line HT 1080. The 2C4 cell line clone expresses the simple cell-surface marker CD2 (normally expressed only on T cells) under the control of the 9-27 gene promoter. The 9-27 gene promoter is inducible by interferon gamma.

Contributors

Inventor Institute
George Stark ; Ian Kerr Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 154235
Product description: The 2C4 cell line is a clonal derivative of the human fibrosarcoma cell line HT 1080. The 2C4 cell line clone expresses the simple cell-surface marker CD2 (normally expressed only on T cells) under the control of the 9-27 gene promoter. The 9-27 gene promoter is inducible by interferon gamma.
Cellosaurus ID: CVCL_1D50
Parental cell line: HT 1080
Disease: Cancer
Cat. #: 154235
Provenance and Ownership: The 2C4 cell line is owned by Cancer Research UK. CancerTools supplies the 2C4 cell line under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing 2C4 cell line directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Continuous
Unit size: 1×10^6 cells / vial
Research Fields: Cancer; Cell signaling and signal transduction; Immunology
Organism: Human
Cancer Types In Detail: Fibrosarcoma
Format: Frozen
Storage conditions: Liquid Nitrogen
Shipping conditions: Dry ice
Growth medium: DMEM + 10% heat-inactivated FBS + 400ug G418 per ml (As described by Kohlhuber et al., 1997)
Mycoplasma free: Yes
Biosafety level: 1
References:

Kohlhuber et al. 1997. Mol Cell Biol. 17(2):695-706. PMID: 9001223.

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Watling et al. 1993. Nature. 366(6451):166-70. PMID: 7901766.

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

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