1BR3-hTERT cell line knockout for PBRM1 (clone 4)
| Inventor | Institute |
|---|---|
| Jessica Downs, Hugang Feng | The Institute of Cancer Research |
| SKU: | 161849 |
|---|---|
| Product description: | 1BR3-hTERT cell line knockout for PBRM1 (clone 4). This cell line has been used for genotypic screening of cancer to predict response to immunotherapies. Specifically to identify functional proteins involved in chromatin re-modelling and how their loss-of-function can regulate DNA damage-induced inflammatory signalling and sensitivity to T-cell-mediated cell killing. |
| Gender: | Male |
| CRISPR: | Yes |
| Conditional: | No |
| Parental cell line: | 1BR3-hTERT |
| Model description: | PBRM1 knockout |
| Products or characteristics of interest: | Gene loss-of-function, chromatin-remodelling, DNA damage, cell cycle response, regulation of t-cell-mediated cell killing. |
| Cat. #: | 161849 |
|---|---|
| Organism: | Human |
| Tissue: | skin |
| Gender: | Male |
| Model: | Genetically modified ; immortalised non-cancer cells |
| Morphology: | Fibroblast |
| Growth properties: | Adherent |
| Format: | Frozen |
|---|---|
| Storage conditions: | Liquid Nitrogen |
| Shipping conditions: | Dry ice |
| Growth medium: | DMEM + 10S + 1% Penicillin/Streptomycin |
| Temperature: | 37C |
| Atmosphere: | 5% CO2 in air |
| Biosafety level: | 1 |
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