Delta proteins activate Notch through a binding reaction that depends on their extracellular domains; they play a key role in the control of cell differentiation by lateral inhibition.
| Inventor | Institute |
|---|---|
| Gavin Wright | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151283 |
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| Product description: | Delta proteins activate Notch through a binding reaction that depends on their extracellular domains; they play a key role in the control of cell differentiation by lateral inhibition. DeltaD is widely expressed in subsets of cells in the nervous system, mesoderm, gut, and elsewhere. Deltas associate with membrane-associated scaffolding proteins MAGI1, MAGI2 and MAGI3. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Extracellular domain; DeltaD peptide |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151283 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Developmental biology; Neurobiology |
| Application: | ELISA ; FACS ; IHC ; IF ; WB |
| Target: | Zebrafish DeltaD extracellular domain |
| Reactivity: | Zebrafish |
| Clone: | zdd2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Delta proteins activate Notch through a binding reaction that depends on their extracellular domains; they play a key role in the control of cell differentiation by lateral inhibition. DeltaD is widely expressed in subsets of cells in the nervous system, mesoderm, gut, and elsewhere. Deltas associate with membrane-associated scaffolding proteins MAGI1, MAGI2 and MAGI3. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sharma et al. 2019. Sci Rep. 9(1):9958. PMID: 31292468. Tong et al. 2019. Methods Mol Biol. 1576:273-281. PMID: 28434166. Gallagher et al. 2017. Dev Biol. 429(1):225-239. PMID: 28648842. Rothschild et al. 2013. Dev Biol. 381(1):179-88. PMID: 23747599. Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612. DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock. Fujita et al. 2011. Development. 138(9):1705-15. PMID: 21429985. Hong et al. 2011. PLoS One. 6(4):e19076. PMID: 21533047. Crosnier et al. 2005. Development. 132(5):1093-104. PMID: 15689380. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Wright et al. 2004. Development. 131(22):5659-69. PMID: 15509766. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Itoh et al. 2003. Dev Cell. 4(1):67-82. PMID: 12530964. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. |
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