This antibody is useful for the detection of WIPI-2, an essential protein for autophagy.
| Inventor | Institute |
|---|---|
| Sharon Tooze | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151651 |
|---|---|
| Product description: | This antibody is useful for the detection of WIPI-2, an essential protein for autophagy. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 49 kDa |
| Immunogen: | Synthetic peptide corresponding to C-terminus of WIPI2b CSALRLDEDSEHPPMILRTD |
| Cat. #: | 151651 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cancer;Tissue-specific biology |
| Application: | IF ; FACS ; IF ; IP ; WB |
| Target: | WIPI2 |
| Reactivity: | Human ; Mouse |
| Clone: | 2A2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | WIPI2 is a mammalian effector of PtdIns3P and is ubiquitously expressed in a variety of cell lines. WIPI2 is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. WIPI-2 is the mammalian homologue of Atg18. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Nishimura et al. 2017. EMBO J. 36(12):1719-1735. PMID: 28495679. Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains. Martinez-Martin et al. 2017. Science. 355(6325):641-647. PMID: 28183981. A switch from canonical to noncanonical autophagy shapes B cell responses. Polson et al. 2010. Autophagy. 6(4):506-22. PMID: 20505359. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Li et al. 2005. J Biol Chem. 280(29):26941-52. PMID: 15917248. Krppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. Benzeno et al. 2004. Cancer Res. 64(11):3885-91. PMID: 15172998. Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151019 | Anti-Mos [S3.1] |
Key Info
Anti-Mos [S3.1]
|
View Tool | |||||||||||||||||||
| 151025 | Anti-Vascular endothelium [10] |
Key Info
Anti-Vascular endothelium [10]
|
View Tool | |||||||||||||||||||
| 151040 | Anti-CD11 & CD18 [24] |
Key Info
Anti-CD11 & CD18 [24]
|
View Tool | |||||||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||||||
| 151039 | Anti-Integrin aVb3 [23C6] |
Key Info
Anti-Integrin aVb3 [23C6]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.