The monoclonal antibody RFF-VIII:R/1 specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg).
| Inventor | Institute |
|---|---|
| Alison Goodall | University College London (UCL) |
| Cat. #: | 151527 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Stem cell biology;Tissue-specific biology |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; Fn ; RIA ; WB |
| Target: | Von Willebrand factor (VWF) |
| Reactivity: | Primate |
| Clone: | RFF-VIII:R/2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The monoclonal antibody RFF-VIII:R/1 specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg). This antibody is a potent inhibitor of von Willebrand factor activity in that it can totally neutralise risocetin-induced aggregation of platelet rich plasma and inhibit platelet adhesion at high flow rates. RFF-VIII:R/1 can be used in a one-stage, fluid phase immunoradiometri… |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Purified human Factor VIII-VWF complex |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | The monoclonal antibody RFF-VIII:R/1 specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg). This antibody is a potent inhibitor of von Willebrand factor activity in that it can totally neutralise risocetin-induced aggregation of platelet rich plasma and inhibit platelet adhesion at high flow rates. RFF-VIII:R/1 can be used in a one-stage, fluid phase immunoradiometri… |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
[Use of RFF-VIII:R/1 in the purification of FVIII] Murdock et al. 1997. Thromb Haemost. 78(4):1272-7. PMID: 9364997. von Willebrand factor activity detected in a monoclonal antibody-based ELISA: an alternative to the ristocetin cofactor platelet agglutination assay for diagnostic use. Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089. Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies. McCraw et al. 1987. Thromb Res. 45(1):1… |
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