Anti-uncarboxylated osteocalcin (ucOC) [Fab-2]

Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation.

Contributors

Inventor Institute
Kaisa Ivaska-Papaioannou ; Urpo Lamminmäki University of Turku
SKU: 157724
Product description: Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin. Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Uncarboxylated osteocalcin (ucOC) may participate in the regulation of glucose metabolism, thus measurement of ucOC could be useful in evaluating interactions between bone and glucose …
Alternate name: Uncarboxylated osteocalcin, uc-Osteocalcin, uc-OC, bone gamma-carboxyglutamic acid-containing protein, BGLAP
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Human full-length ucOC peptide (149, Glu at positions 17, 21 and 24; C23C29 bridge)
Cat. #: 157724
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Disease (not cancer); Metabolism
Application: IF ; Fn
Target: osteocalcin – partially carboxylated with Glu at position 17 and 21
Reactivity: Human
Host: Human
Class: Recombinant
Target background: Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin. Osteocalcin is a bone-specific protein which contains three glutamic acid residues (Glu) that undergo post-translational gamma-carboxylation. Uncarboxylated osteocalcin (ucOC) may participate in the regulation of glucose metabolism, thus measurement of ucOC could be useful in evaluating interactions between bone and glucose …
Format: Liquid
Concentration: 1 mg/ml
Storage conditions: -20° C
Shipping conditions: Dry ice
References:

Arponen et al. 2020. Calcif Tissue Int. 107(6):529-542. PMID: 32839842.

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