The Ufd1 protein (human gene: UFD1L) forms a heterodimer with another protein, Npl4. Ufd1-Npl4 serves as an ubiquitin-adapter for the VCP/p97 AAA ATPase. The ATPase complex is required for endoplasmic reticulum-associated degradation and regulation of spindle dynamics, and nuclear envelope formation after mitosis.
| Institute |
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| Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151414 |
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| Product description: | The Ufd1 protein (human gene: UFD1L) forms a heterodimer with another protein, Npl4. Ufd1-Npl4 serves as an ubiquitin-adapter for the VCP/p97 AAA ATPase. The ATPase complex is required for endoplasmic reticulum-associated degradation and regulation of spindle dynamics, and nuclear envelope formation after mitosis. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 40 kDa |
| Immunogen: | Full length mouse Ufd1 expressed in E. coli |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151414 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology |
| Application: | ELISA ; IF ; IP ; WB |
| Target: | Ufd1 |
| Reactivity: | Human ; Rat ; Mouse ; Xenopus laevis |
| Clone: | 500 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The Ufd1 protein (human gene: UFD1L) forms a heterodimer with another protein, Npl4. Ufd1-Npl4 serves as an ubiquitin-adapter for the VCP/p97 AAA ATPase. The ATPase complex is required for endoplasmic reticulum-associated degradation and regulation of spindle dynamics, and nuclear envelope formation after mitosis. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Cao et al. 2003. Cell. 115(3):355-67. PMID: 14636562. The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Hetzer et al. 2001. Nat Cell Biol. 3(12):1086-91. PMID: 11781570. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Meyer et al. 2000. EMBO J. 19(10):2181-92. PMID: 10811609. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. |
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