An anti-tap63 mouse monoclonal antibody
| Institute |
|---|
| Moravian Biotechnology |
| SKU: | 162057 |
|---|---|
| Product description: | Antibody created to detect the TA isoform of p63 (TAp63) with tumour suppressor role and differentiate from the deltaN (deltaNp63) isoforms of the same protein. Binding specificity: epitope mapping using phage disply identified the epitope LSDPxW for all clones. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Molecular weight: | 76 kD |
| Immunogen: | Recombinant human TAp63delta |
| Cat. #: | 162057 |
|---|---|
| Tool sub type: | Primary antibody |
| Target: | transactivation domain of tumour protein p63 |
| Reactivity: | Human ; mouse ; rat |
| Clone: | TAp63-4.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | p63 is a transcription factor of the p53 gene family, encoded by the TP63 gene located at chromosome 3q28. p63 exists as N-terminal isoforms that either contain (TAp63) or lack (deltaNp63) the p53-like transactivation domain at the N-terminus. C-terminal isoforms are produced by alternative splicing of 3′ exons. TAp63 is involved in germ cell maintenance and myocyte differentiation, and is expressed in some lymphocytes and lymphomas/leukaemias. |
|---|
| Format: | Liquid |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Orzol et al. 2016. Tumour Biol. Aug:37(8):10133-40. PMID: 26825981 Galoczova et al. 2021. Virchows Arch. Apr:478(4):627-636. PMID: 33037932 Pokorna et al. 2022. Front Oncol. Jul 14:12:924354. PMID: 35912167 |
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