Monoclonal antibody directed at large T antigen of SV40, valuable for investigation into other SV40 tumour antigens and polyomaviruses.
| Inventor | Institute |
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| Lionel Crawford | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| SKU: | 153338 |
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| Product description: | Monoclonal antibody directed at large T antigen of SV40, valuable for investigation into other SV40 tumour antigens and polyomaviruses. Background and Research Application Anti-SV40T which binds to the large T antigen of the Simian oncogenic polyoma virus (SV40). Both the Simian virus (SV40) large T and small T antigens are encoded by the early region of the SV40 genome. The SV40 large T antigen is an early protein that interacts with the p53 and Rb tumour suppressor proteins. Large T is cap… |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 94 kDa |
| Immunogen: | SV40 transformed mouse cells |
| Immunogen Uniprot ID: | P03070 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 153338 |
|---|---|
| Provenance and Ownership: | The Anti-SV40T [PAB416] is owned by Cancer Research UK. CancerTools supplies the Anti-SV40T [PAB416] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-SV40T [PAB416] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Other |
| Research Fields: | Microbiology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | N-terminal domain of SV40 large and small T-antigen |
| Reactivity: | Virus |
| Clone: | PAb416 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Monoclonal antibody directed at large T antigen of SV40, valuable for investigation into other SV40 tumour antigens and polyomaviruses. Background and Research Application Anti-SV40T which binds to the large T antigen of the Simian oncogenic polyoma virus (SV40). Both the Simian virus (SV40) large T and small T antigens are encoded by the early region of the SV40 genome. The SV40 large T antigen is an early protein that interacts with the p53 and Rb tumour suppressor proteins. Large T is ca… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Tanaka et al. 2018. J Vet Med Sci. 80(9):1400-1406. PMID: 30012933. Pelletier et al. 2018. Histopathology. 73(1):162-166. PMID: 29430700. Rigatti et al. 2016. mSphere. 1(6):. PMID: 28028546. Toptan et al. 2016. JCI Insight. 1(2):. PMID: 27034991. Chiaravalli et al. 2013. J Clin Pathol. 66(1):44-9. PMID: 23012397. Sabatier et al. 2005. J Clin Pathol. 58(4):429-31. PMID: 15790713. Immunodetection of SV40 large T antigen in human central nervous system tumours. Radhakrishnan et al…. |
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