Transcription factor SOX9 recognizes the sequence “CCTTGAG” as do other members of the high mobility group-box class DNA-binding proteins.
| Inventor | Institute |
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| Vincent Harley | Hudson Institute Of Medical Research |
| SKU: | 153658 |
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| Product description: | The Sox genes are a family of genes related to the mammalian sex determining gene ex-determining region Y protein (SRY). SOX genes genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators which have been implicated in the process of development and cell fate. At present 30 Sox genes have been identified and members of the family are conserved during evolution…. |
| Alternate name: | SOX9, CMPD1, CMD1, SRA1 |
| Conjugation: | Unconjugated |
| Immunogen: | Synthetic Human SOX9 peptide |
| Cat. #: | 153658 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | ChIP ; IF ; WB |
| Target: | SOX9 |
| Reactivity: | Chicken ; Human ; Mouse ; Rabbit |
| Host: | Rabbit |
| Class: | Polyclonal |
| Target background: | The Sox genes are a family of genes related to the mammalian sex determining gene ex-determining region Y protein (SRY). SOX genes genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators which have been implicated in the process of development and cell fate. At present 30 Sox genes have been identified and members of the family are conserved during evolution…. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Zwolanek et al. 2017. JCI Insight. 2(20):. PMID: 29046476. Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model. Qi et al. 2017. Nat Commun. 8:13824. PMID: 28059064. BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Kim et al. 2017. J Clin Invest. 127(1):137-152. PMID: 27869648. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. … |
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