Snail1 therefore has a strong association with metastatic disease.
| Inventor | Institute |
|---|---|
| Melanie Hardman | Cancer Research Technology |
| SKU: | 151548 |
|---|---|
| Product description: | The Snail superfamily are zinc finger transcription factors. Overexpression of Snail1 can lead to cells undergoing EMT (epithelial to mesenchymal transition). This is achieved as Snail1 represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin. Snail1 therefore has a strong association with metastatic disease. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Immunogen: | Human Snail 1 recombinant protein |
| Cat. #: | 151548 |
|---|---|
| Provenance and Ownership: | The Anti-SNAIL1 [20C8] is owned by Cancer Research UK. CancerTools supplies the Anti-SNAIL1 [20C8] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-SNAIL1 [20C8] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Ovarian cancer; Breast cancer |
| Research Fields: | Cancer; Genetics; Tissue-specific biology |
| Application: | WB ; ChIP ; ELISA ; IHC ; IF ; IP ; WB |
| Target: | SNAIL1 |
| Reactivity: | Human |
| Clone: | 20C8 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The Snail superfamily are zinc finger transcription factors. Overexpression of Snail1 can lead to cells undergoing EMT (epithelial to mesenchymal transition). This is achieved as Snail1 represses expression of E-cadherin, desmoplakin, muc-1, cytokeratin18 while enhances expression of vimentin and fibronectin. Snail1 therefore has a strong association with metastatic disease. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Yang et al. 2018. Exp Mol Med. 50(1):e420. PMID: 29303507. Goldman et al. 2016. Stem Cell Res. 17(1):62-8. PMID: 27240252. Ju et al. 2015. Cell Death Dis. 6:e1801. PMID: 26136074. Tuhkanen et al. 2009. BMC Cancer. 9:289. PMID: 19695091. Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression. Vincent et al. 2009. Nat Cell Biol. 11(8):943-50. PMID: 19597490. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Franc et al. 2006. Oncogene. 25(37):5134-44. PMID: 16568079. Expression of Snail protein in tumor-stroma interface. |
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