Anti-Senataxin [OY11]

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The staining pattern of the antibody is located in the nucleus and chromatin.

Contributors

Inventor Institute
Stephen West Cancer Research UK, London Research Institute: Clare Hall Laboratories
SKU: 151842
Product description: Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin.
Conjugation: Unconjugated
Molecular weight: 303 kDa
Immunogen: A mixture of four peptides corresponding to the following amino acid ranges of human Senataxin: aa8-30, aa884-895, aa1173-1192, aa2654-2677
Cat. #: 151842
Provenance and Ownership: The Anti-Senataxin [OY11] is owned by Cancer Research UK. CancerTools supplies the Anti-Senataxin [OY11] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Senataxin [OY11] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics; Neurobiology
Application: IP ; WB
Target: Senataxin
Reactivity: Human
Clone: OY11
Host: Rabbit
Class: Polyclonal
Target background: Defects in Senataxin are the cause of neurodegenerative diseases AOA-2 and ALS4. Senataxin play vital roles in DNA repair and transcription termination. The staining pattern of the antibody is located in the nucleus and chromatin.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl.
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Yce et al. 2013. Mol Cell Biol. 33(2):406-17. PMID: 23149945.

Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.

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