RAET1E (retinoic acid early transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes.
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| University of Cambridge |
| SKU: | 151542 |
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| Product description: | RAET1E (retinoic acid early transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a functional ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Recombinant His-tagged protein to human extra-cellular domain of RAET1E produced in E.coli (33-227) with a N terminal 6x His tag. |
| Cat. #: | 151542 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | ELISA ; FACS ; IF ; IP ; Fn ; WB |
| Target: | RAET1E |
| Reactivity: | Human |
| Clone: | RAET1E 119/6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | RAET1E (retinoic acid early transcript 1E), or ULBP4, is a member of the RAET1 family of major histocompatibility complex (MHC) class I-related genes. RAET1E and RAET1G differ from the other RAET1 proteins by having a type I membrane-spanning sequence at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a Fn ligand for NKG2D, which causes lymphocyte activation resulting in the secretion of cytokines. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Cao et al. 2007. J Biol Chem. 282(26):18922-8. PMID: 17470428. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. Bacon et al. 2004. J Immunol. 173(2):1078-84. PMID: 15240696. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. Chalupny et al. 2003. Biochem Biophys Res Commun. 305(1):129-35. PMID: 12732206. ULBP4 is a novel ligand for human NKG2D. |
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