RAD51C is a RAD51 paralogue. Rad51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway.
| Inventor | Institute |
|---|---|
| Madalena Tarsounas | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151457 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IP ; WB |
| Target: | Rad51C |
| Reactivity: | Mouse |
| Clone: | MTA36 |
| Host: | Rabbit |
| Class: | Polyclonal |
| Product description: | RAD51C is a RAD51 paralogue. Rad51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway of DNA repair. |
|---|---|
| Conjugation: | Unconjugated |
| Immunogen: | Mouse n-terminal RAD51C peptide . |
| Target background: | RAD51C is a RAD51 paralogue. Rad51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway of DNA repair. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Badie et al. 2009. J Cell Biol. 185(4):587-600. PMID: 19451272. RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. |
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