Anti-RACO1 [5H10]

RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.

Contributors

Inventor Institute
Axel Behrens Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151685
Product description: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.
Alternate name: Ring Finger Protein 187; RING Domain AP1 Coactivator 1; Protein RNF187; RACO1
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Single C-terminal immunogenic peptide
Myeloma used: Sp2/0-Ag14
Cat. #: 151685
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: ELISA ; IP ; WB
Target: RACO1
Reactivity: Human ; Mouse ; Rat
Clone: 5H10
Host: Mouse
Class: Monoclonal
Target background: RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Davies et al. 2010. Nat Cell Biol. 12(10):963-72. PMID: 20852630.

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

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