| Institute |
|---|
| Helmholtz Munich Core Facility Monoclonal Antibodies |
| SKU: | 162376 |
|---|---|
| Product description: | Antibody for the human primase p58, or human p58 protein kinase, of PRIM2. Applicable to numerous tumour types – its role in cancer is intimately linked to its essential function in DNA replication and genome maintenance. |
| Alternate name: | Anti human primase p58 monoclonal antibody (clone PRI-5G6) |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Recombinant primase p58 subunit |
| Cat. #: | 162376 |
|---|---|
| Tool sub type: | Primary antibody |
| Research Fields: | Cancer; Cell biology |
| Application: | WB |
| Target: | Human primase p58 |
| Reactivity: | Human |
| Clone: | PRI-5G6 |
| Host: | Rat |
| Class: | Monoclonal |
| Primary citation: | Weisshart et al. 2000. J. Biol. Chem. 275: 17328-17337. PMID: 10747950 |
| Target background: | Primase p58 (also known as PRIM2 or PriL) is a large regulatory subunit of DNA primase, an enzyme crucial for DNA replication in eukaryotes. DNA primase, in complex with DNA polymerase alpha, synthesizes short RNA primers that are essential for initiating new DNA strands on both the leading and lagging strands during DNA replication. |
|---|
| References: |
Weisshart et al. 2000. J. Biol. Chem. 275: 17328-17337. PMID: 10747950 |
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