Anti-PKD

Contributors

Inventor Institute
Abdo Alnabulsi Vertebrate Antibodies Limited
SKU: 158062
Product description: Proliferative kidney disease (PKD), caused by the myxozoan parasite Tetracapsuloides bryosalmonae, is one of the most economically damaging diseases to trout aquaculture. T. bryosalmonae has a two-host life cycle, as other myxosporeans, cycling between freshwater bryozoan and salmonid fish species. It is characterised by a swollen kidney and spleen, bloody ascites, and pale gills, indicating the fish becomes anemic at the late stage of the disease. This parasite is allowed to cross the renal tubules wall to proliferate within the interstitial tissue of kidney, inducing a chronic lymphoid hyperplasia marked by a strong parasite-driven immunosuppressant pathogenesis and a dysregulation of T-helper subsets. Fish recovering from PKD develop protective immunity to subsequent parasite challenge, providing the impetus for vaccine development. A polyclonal antibody used to identify T. bryosalmonae antigens will be able to elicit protective immune responses for developing DNA vaccines. This is a useful diagnostic tool to identify T. bryosalmonae parasite. This antibody is potentially neutralizing providing a valuable research tool to study parasite-host interactions and vaccine development.
Conjugation: Unconjugated
Molecular weight: 31
Immunogen: Ovalbumin-conjugated synthetic peptide.
Cat. #: 158062
Unit size: 100 ug
Research Fields: Cell biology; Immunology
Application: ELISA ; IHC ; WB
Target: Tetracapsuloides bryosalmonae parasite antigen
Reactivity: Tetracapsuloides bryosalmonae
Host: Rabbit
Class: Polyclonal
Target background: Proliferative kidney disease (PKD), caused by the myxozoan parasite Tetracapsuloides bryosalmonae, is one of the most economically damaging diseases to trout aquaculture. T. bryosalmonae has a two-host life cycle, as other myxosporeans, cycling between freshwater bryozoan and salmonid fish species. It is characterised by a swollen kidney and spleen, bloody ascites, and pale gills, indicating the fish becomes anemic at the late stage of the disease. This parasite is allowed to cross the renal tubules wall to proliferate within the interstitial tissue of kidney, inducing a chronic lymphoid hyperplasia marked by a strong parasite-driven immunosuppressant pathogenesis and a dysregulation of T-helper subsets. Fish recovering from PKD develop protective immunity to subsequent parasite challenge, providing the impetus for vaccine development. A polyclonal antibody used to identify T. bryosalmonae antigens will be able to elicit protective immune responses for developing DNA vaccines. This is a useful diagnostic tool to identify T. bryosalmonae parasite. This antibody is potentially neutralizing providing a valuable research tool to study parasite-host interactions and vaccine development.
Format: Liquid
Storage buffer: Unpurified anti-serum from rabbit preserved in 0.02% Thiomersal
Shipping conditions: Dry ice

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