| Institute |
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| Johns Hopkins University |
| SKU: | 156435 |
|---|---|
| Product description: | Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. Phosphoinositide interacting regulator of TRP (Pirt), a membrane protein, expressed specifically in the peripheral nervous system (PNS), predominantly in nociceptive (pain) neurons has been described by several experiments indicating that Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. To further study this signaling pathway, a rabbit polyclonal anti-Pirt antibody that recognizes the Pirt protein has been developed. |
| Conjugation: | Unconjugated |
| Cat. #: | 156435 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction |
| Application: | IHC |
| Target: | phosphoinositide interacting regulator of TRP (Pirt) |
| Reactivity: | Human |
| Host: | Rabbit |
| Class: | Polyclonal |
| Target background: | Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. Phosphoinositide interacting regulator of TRP (Pirt), a membrane protein, expressed specifically in the peripheral nervous system (PNS), predominantly in nociceptive (pain) neurons has been described by several experiments indicating that Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. To further study this signaling pathway, a rabbit polyclonal anti-Pirt antibody that recognizes the Pirt protein has been developed. |
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| Format: | Liquid |
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| Shipping conditions: | Dry ice |
| References: |
Kim et al. 2008. Cell. 133(3):475-85. PMID: 18455988. |
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