Anti-PD-1H [MH5A]

This antibody has been shown to prevent acute graft versus host disease (GVHD) in semi-and fully-allogeneic mouse models, resulting in full chimerism after treatment.

Contributors

Inventor Institute
Leiping Chen Yale University
SKU: 159686
Product description: Programmed Death-1 Homolog (PD-1H) is a cell surface immunoglobulin super family molecule which is expressed constitutively on the surface of hematopoetic cells (T cells, NK cells, monocytes, and DCs) and regulates differentiation of osteoblast, adipocyte, and embryonic cells. It has also been shown to regulate cell apoptosis. PD-1H acts mainly as a coinhibitor in the T cell initiation of T cell responses to antigens and is critical for the differentiation and stability of inducible T regulatory cells. This antibody has been shown to prevent acute graft versus host disease (GVHD) in semi-and fully-allogeneic mouse models, resulting in full chimerism after treatment.
Alternate name: VISTA, Gi24, Dies1, B7-H5, DD1a
Conjugation: Unconjugated
Immunogen: mPD-1HIg fusion protein
Myeloma used: Sp2/0
Cat. #: 159686
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Immunology
Application: IHC ; FACS
Target: Programmed Death-1 Homolog
Reactivity: Mouse
Host: Hamster
Class: Monoclonal
Target background: Programmed Death-1 Homolog (PD-1H) is a cell surface immunoglobulin super family molecule which is expressed constitutively on the surface of hematopoetic cells (T cells, NK cells, monocytes, and DCs) and regulates differentiation of osteoblast, adipocyte, and embryonic cells. It has also been shown to regulate cell apoptosis. PD-1H acts mainly as a coinhibitor in the T cell initiation of T cell responses to antigens and is critical for the differentiation and stability of inducible T regulatory cells. This antibody has been shown to prevent acute graft versus host disease (GVHD) in semi-and fully-allogeneic mouse models, resulting in full chimerism after treatment.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Flies et al. 2011. J Immunol. 187(4):1537-41. PMID: 21768399.

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