Anti-PCNA monoclonal antibody [16D10]

Contributors

Institute
Helmholtz Munich Core Facility Monoclonal Antibodies
SKU: 162378
Product description: Antibody for PCNA (proliferating cell nuclear antigen), a key protein involved in cell cycle regulation, particularly during DNA replication and repair. Its dysregulation is linked to cancer development.
Alternate name: Anti PCNA (clone 16D10)
Conjugation: Unconjugated
Immunogen: Recombinant 6xHis-tagged PCNA
Cat. #: 162378
Tool sub type: Primary antibody
Cancer types: Breast cancer
Research Fields: Cancer; Cell biology
Application: IP
Target: Proliferating Cell Nuclear Antigen (PCNA)
Reactivity: Human
Clone: 16D10
Host: Rat
Class: Monoclonal
Primary citation: Spada et al. 2007. J Cell Biol. 176(5): 565-71. PMID: 17312023
Target background: PCNA (Proliferating Cell Nuclear Antigen) is a sliding clamp for DNA polymerases during DNA replication that coordinates the orderly duplication of the genome by increasing the processivity of DNA polymerase delta. PCNA weighs approximately 29 kDa and forms a homotrimeric ring structure. It is expressed in the nucleus of cells found at high levels in proliferating cells.
References:

Spada et al. 2007. J Cell Biol. 176(5): 565-71. PMID: 17312023

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