Anti-pan-late cornified envelope 3, pan-LCE3 [7]

Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.

Contributors

Inventor Institute
Joost Schalkwijk Radboud University Medical Center (UMC)
SKU: 160445
Product description: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defence. They have been shown to posses antibacterial (gram positive and negative, aerobic and anaerobic species) properties. During inflammation they have been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins have been shown to be a significant risk factor in psoriasis.
Alternate name: Late envelope protein 16, Small proline-rich-like epidermal differentiation complex protein 6A, Small proline-rich-like epidermal differentiation complex protein 6B
Conjugation: Unconjugated
Immunogen: Late cornified envelope protein 3B
Myeloma used: Sp2/0
Cat. #: 160445
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Immunology
Application: ELISA ; IHC ; IF
Target: Late cornified envelope (LCE) protein 3
Reactivity: Human
Host: Mouse
Class: Monoclonal
Target background: The LCE3 proteins are structural components of the cornified envelope of the stratum corneum and may be involved in innate cutaneous host defense. They ahve been shown to posses antibacterial (gram positive and negative, aerobic and anearobic speacies) properties. During inflammation they haev been shown to be involved in skin repair (PMID: 28634035). Deletion of LCE3B and LCE3C proteins has been shown to be a significant risk factor in psoriasis.
Format: Liquid
Shipping conditions: Dry ice
References:

Niehues et al. 2016. Br J Dermatol. 174(4):795-802. PMID: 26556599.

Images

View Gallery
Late cornified envelope (LCE)3 protein peptide recognition pattern. (a) Affinity data of anti?LCE3 monoclonal antibody against different LCE3 proteins based on enzyme?linked immunosorbent assay (ELISA) analysis; and comparison of the epitope sequences in the LCE3 members. The LCE3B peptide was used for mouse immunization. (b) Immunohistochemical staining of LCE3 proteins in normal human epidermis with the developed anti?LCE3 monoclonal antibody. The picture is representative for the expression in three different skin biopsies. (c) Staining of LCE3 proteins in normal human skin after competition with our anti?LCE3 antibody and LCE peptides. Scale bar = 100 ?m.

Related Tools for Antibodies

Cat. # Tool Name
151015 Anti-CyclinA [E70.1] Key Info View Tool
151031 Anti-RuvA [RuvA 12C6] Key Info View Tool
151026 Anti-FCGR1 [10.1] mAb Key Info View Tool
151029 Anti-HSVICP8 [11E2] Key Info View Tool
151038 Anti-Cytochrome P450 4A2, 4A3 [Clo4] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.