Anti-p53 [Pab 1802]

Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells.

Contributors

Inventor Institute
Lawrence Banks Cancer Research UK, London Research Institute: Lincoln's Inn Fields
SKU: 151145
Product description: Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells.
Alternate name: Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 53 kDa
Immunogen: P53-beta galactosidase fusion protein
Myeloma used: P3/NS1/1-Ag4.1
Cat. #: 151145
Tool sub type: Primary antibody
Unit size: 100 ug
Application: ELISA ; IHC ; IP ; WB
Target: p53
Reactivity: Human ; Mouse
Clone: Pab 1802
Host: Mouse
Class: Monoclonal
Primary citation: Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.
Target background: p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the “guardian of the genome,” p53 prevents gene mutations. Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of fun…
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.

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