PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
| Inventor | Institute |
|---|---|
| Lionel Crawford | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151143 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | IHC ; IP |
| Target: | p53 |
| Reactivity: | Human |
| Clone: | Pab 1104 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796. |
| Product description: | PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 53 kDa |
| Immunogen: | A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis. |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151. Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs. Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746. An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53. Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796. Monoclonal antibodies displaying a novel spe… |
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