Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage.
| Inventor | Institute |
|---|---|
| Lawrence Banks | International Centre For Genetic Engineering And Biotechnology (ICGEB) |
| SKU: | 153964 |
|---|---|
| Product description: | Rabbit anti-human p53 polyclonal recognises a 53kDa cytoplasmic/nuclear protein up regulated in response to DNA damage. |
| Alternate name: | Tumour Protein p53, Cellular Tumour Antigen p53, Phosphoprotein p53, Antigen NY-CO-13 |
| Conjugation: | Unconjugated |
| Molecular weight: | 53 kDa |
| Immunogen: | C-terminal 14 amino acids of human p53 |
| Cat. #: | 153964 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Other |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell signaling and signal transduction |
| Application: | IF ; IP ; WB |
| Target: | p53 |
| Reactivity: | Human |
| Host: | Rabbit |
| Class: | Polyclonal |
| Target background: | p53 has been described as the ‘guardian of the genome’ because of its role in conserving stability by preventing genome mutation. The TP53 gene is the most frequently mutated gene (>50%) in human cancer. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | Serum |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Thomas et al. 1999. Mol Cell Biol. 19(2):1092-100. PMID: 9891044. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Thomas et al. 1996. Oncogene. 13(3):471-80. PMID: 8760288. HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence. |
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