Anti-ORF45 [8B8]

Kaposi’s sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi’s sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been […]

Contributors

Inventor Institute
Fanxiu Zhu Florida State University Research Foundation
Cat. #: 160643
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics;Microbiology
Application: IP
Target: Open Reading Frame 45 clone [8B8]
Reactivity: Other Species
Host: Mouse
Class: Monoclonal
Product description: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015). ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen. This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.
Conjugation: Unconjugated
Isotype: IgG
Immunogen: A baculovirus-synthesized ORF45 was used as an antigen
Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) has been identified as the causative agent of Kaposi's sarcoma, the most common malignancy in HIV-infected individuals. KSHV has also been shown to be be associated with two lymphoproliferative diseases (Fu et al., 2015).ORF45 (tegument) is a gene associated with the lytic viral life cycle of KSHV and has been shown to have multiple functions throughout the viral life cycle. ORF45 is a crucial component of progeny virion production in conjunction with ORF33. ORF45 binds to and stabilizes ORF33. This anti-ORF45 has been shown to purify different populations of ORF45 as well as enable the targeted depletion or enrichment of subpopulations of ORF45. This anti-ORF45 was generated using a baculovirus-synthesized ORF45 as an antigen.This specific Anti-ORF45 mouse monoclonal antibody clone [8B8] was developed for the isolation of ORF45 under native conditions via immunoaffinity purification.
Format: Liquid
Shipping conditions: Dry ice
References:

Fu et al. 2015. J Virol. 89(1):195-207. PMID: 25320298.

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