A monoclonal antibody recognising neonatal Nav1.5, used to study voltage-gated sodium channel expression in cancer and metastatic behaviour research.
| Inventor | Institute |
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| Caroline Foxton | Cancer Research Technology |
| SKU: | 151409 |
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| Product description: | Anti-nNav 1.5 [4G8:1G7] is a monoclonal antibody that recognises neonatal Nav1.5, a voltage-gated sodium channel variant. It is used to detect and study nNav1.5 expression, supporting research into voltage-gated sodium channel biology and the role of nNav1.5 in tumour cell behaviour, including breast and prostate cancer cell metastasis. |
| Additional notes: | Voltage-gated sodium channel expression has been detected in tumour cell lines and has been implicated in metastatic behaviour of breast and prostate cancer cells. |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 180-200 kDa |
| Immunogen: | Peptide (14mer) from an extracellular domain of Nav1.5 – VSENIKLGNLSALR |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151409 |
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| Provenance and Ownership: | The Anti-nNav 1.5 [4G8:1G7] is owned by Cancer Research UK. CancerTools supplies the Anti-nNav 1.5 [4G8:1G7] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-nNav 1.5 [4G8:1G7] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Neurobiology |
| Application: | FACS ; IHC ; IF ; WB |
| Target: | Neonatal Nav1.5 (Voltage gated Sodium Channel Nav1.5) |
| Reactivity: | Human |
| Clone: | 4G8:1G7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. They have also been detected in lymphocytes, glia, and fibroblasts. VGSC proteins are comprised of a core alpha-subunit, together with one or more additional regulatoy beta-subunit. VCSC expression has been detected in a number of tumour cell lines and has been implicated in the metastatic behaviour of breast and prostate cancer cells. Na(v)1.5, the major cardiac voltage-gated Na(+) channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A which encodes Na(v)1.5. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Vikram et al. 2017. Nat Med. 23(3):361-367. PMID: 28191886. Utrilla et al. 2017. Front Physiol. 8:903. PMID: 29184507. Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436. Guo et al. 2011. Toxicol Sci. 123(1):281-9. PMID: 21693436. |
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