SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tunour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting.
| Inventor | Institute |
|---|---|
| Joyce Taylor-Papadimitriou ; Joy Burchell | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151161 |
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| Product description: | SM3 antibody recognises this under-glycosylated form of MUC1 and is therefore tumour specific and may be relevant for breast cancer therapy. SM3 also detects MUC1 within colon and ovarian cancer and most adenocarcinomas and may be used for immunohistochemistry (reactive with methacarn fixed tissue), and immunotargeting. |
| Alternate name: | ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Immunogen: | Hydrogen fluoride deglycosylated milk mucin. |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151161 |
|---|---|
| Provenance and Ownership: | The Anti-MUC1 [SM3] is owned by Cancer Research UK. CancerTools supplies the Anti-MUC1 [SM3] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-MUC1 [SM3] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Application: | ELISA ; FACS ; IHC |
| Target: | Mucin1 (MUC1) |
| Reactivity: | Human |
| Clone: | SM3 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoitic cell lineages. In the vast majority of human carcinomas, this protein is upregulated, poorly glycosylated and appears on the cell surface in a non-polarised fashion. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Geng et al. 2013. Cell Mol Bioeng. 6(2):148-159. PMID: 23805168. Targeting Underglycosylated MUC1 for the Selective Capture of Highly Metastatic Breast Cancer Cells Under Flow. Srensen et al. 2006. Glycobiology. 16(2):96-107. PMID: 16207894. Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance. Brockhausen et al. 1995. Eur J Biochem. 233(2):607-17. PMID: 7588808. Mechanisms underlying aberrant … |
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