A mouse monoclonal antibody recognising MUC1/epithelial mucin, used to detect and study MUC1 expression in epithelial tumour research.
| Inventor | Institute |
|---|---|
| Mike Price | University of Nottingham |
| SKU: | 153396 |
|---|---|
| Product description: | Anti-MUC1 [C595 (NCRC48)] is a mouse monoclonal antibody that recognises MUC1, also known as epithelial mucin. It is used to detect and study MUC1 expression, supporting research into epithelial tumour biology, mucin expression and MUC1-associated cancer mechanisms. Clone C595 recognises a peptide epitope within the immunodominant tandem repeat region of the MUC1 protein core, reported as RPAP/Arg-Pro-Ala-Pro. |
| Alternate name: | CD227; KL6; Mucin 1; PEMT |
| Conjugation: | Unconjugated |
| Isotype: | IgG3 |
| Molecular weight: | 122 kDa |
| Immunogen: | Urinary MUC-1 mucin (Human) |
| Cat. #: | 153396 |
|---|---|
| Provenance and Ownership: | The Anti-MUC1 [C595 (NCRC48)] is owned by Cancer Research UK. CancerTools supplies the Anti-MUC1 [C595 (NCRC48)] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-MUC1 [C595 (NCRC48)] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Ovarian cancer; Colorectal cancer; Breast cancer |
| Research Fields: | Cancer; Cell biology; Genetics |
| Application: | ELISA ; FACS ; IHC ; WB |
| Target: | MUC1 |
| Reactivity: | Human |
| Clone: | C595 (NCRC48) |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence. Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. Medullary cystic kidney disease 1. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Yew et al. 2013. PLoS One. 8(9):e72637. PMID: 24039787. Guimaraes-Souza et al. 2012. Nephrol Dial Transplant. 27(8):3082-90. PMID: 22287659. |
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