Anti-MTBP [2C1E11]

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Contributors

Inventor Institute
Mark Boyd University of Liverpool
SKU: 151708
Product description: MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).
Alternate name: MDM2 Binding Protein, MDM2 (Mouse Double Minute 2)-Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, MDM2BP, HMTBP
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Recombinant full-length human MTBP
Cat. #: 151708
Provenance and Ownership: The Anti-MTBP [2C1E11] is owned by Cancer Research UK. CancerTools supplies the Anti-MTBP [2C1E11] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-MTBP [2C1E11] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements.
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer; Cell biology; Genetics
Application: WB
Target: MTBP
Reactivity: Human
Clone: 2C1E11
Host: Mouse
Class: Monoclonal
Target background: MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).
Format: Liquid
Concentration: 1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Vlatkovic et al. 2011. Cancer. 117(13):2939-50. PMID: 21692053.

Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.

Images

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Western blot analysis comparing binding to murine and human MTBP. 30ug H1299 protein/well. Mouse antibodies were at a concentration of 3ug/ml. AS-1 rabbit 1

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