Anti-MOAP-1 [4A12]

Contributors

Institute
A*STAR Accelerate Technologies Pte Ltd
SKU: 152644
Product description: MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: GST-MOAP-1 (N-terminal) fusion protein
Myeloma used: Sp2/0-Ag14
Cat. #: 152644
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy; Cancer
Application: IF ; WB
Target: Modulator of apoptosis-1
Reactivity: Human
Clone: 4A12
Host: Mouse
Class: Monoclonal
Target background: MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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Western blot analysis of lysates prepared from U20S cells transfected with myc-MOAP-1 (+) or vector control (-). Detection was performed using an anti-Myc antibody or anti-MOAP-1 [4A12]

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