Anti-MMP3 [1B4]

The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
SKU: 151620
Product description: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Conjugation: Unconjugated
Isotype: IgG1
Immunogen: Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
Myeloma used: P3X63Ag8.653
Cat. #: 151620
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology;Genetics;Tissue-specific biology
Application: ELISA ; IHC ; IF ; IP ; WB
Target: Human matrix metalloproteinase 3 (MMP-3)
Reactivity: Human
Clone: 1B4
Host: Mouse
Class: Monoclonal
Target background: Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Format: Liquid
Storage buffer: PBS with 0.02% azide
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Jeffery et al. 2009. Histopathology. 54(7):820-8. PMID: 19635101.

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.

Lyall et al. 2006. Clin Cancer Res. 12(4):1184-91. PMID: 16489072.

Profiling markers of prognosis in colorectal cancer.

Curran et al. 2004. Clin Cancer Res. 10(24):8229-34. PMID: 15623598.

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.

Murray et al. 1998. Gut. 43(6):791-7. PMID: 9824606.

Matrix metalloproteinases and their inhibitors in gastric cancer.

Murray et al. 1998. J Pathol. 185(3):256-61. PMID: 9771478.

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer.

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