HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an a? heterodimer of type MHC class II. The a and ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both a-chain and ?-chain vary greatly. A person often produces two a-chain and two ?-chain variants and thus 4 isoforms of DQ.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154752 |
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| Product description: | HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an alpha beta heterodimer of type MHC class II. The alpha and beta chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both the alpha and beta chain vary greatly. A person often produces two alpha-chain and two beta-chain variants and thus 4 isoforms of DQ. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Cloned cytotoxic T lymphocytes. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154752 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction; Immunology |
| Application: | FACS ; IHC ; IP |
| Target: | MHC class II HLA-DQ |
| Reactivity: | Human ; Pig |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | HLA-DQ (DQ) is a cell surface receptor protein found on antigen presenting cells. It is an a? heterodimer of type MHC class II. The a and ? chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. Both a-chain and ?-chain vary greatly. A person often produces two a-chain and two ?-chain variants and thus 4 isoforms of DQ. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117. Spits et al. 1984. Eur J Immunol. 14(4):299-304. PMID: 6609821. Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061. |
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