MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal.
| Institute |
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| University of Cambridge |
| SKU: | 151418 |
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| Product description: | Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | His-tagged human Mcm5 (amino acids 367582) |
| Cat. #: | 151418 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; WB |
| Target: | Mini Chromosome Maintenance protein5 (MCM5) |
| Reactivity: | Human |
| Clone: | A2.7A3.F12.A7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Mini Chromosome Maintenance protein-5 (MCM5) is a component of the prereplicative complex that is essential for DNA replication. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. MCM5 expression may be applicable in the detection of a number of cancers including cervical, bladder, lung and oesophageal. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Rakotomalala et al. 2008. J Biol Chem. 283(42):28729-40. PMID: 18693245. Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. Williams et al. 1998. Proc Natl Acad Sci U S A. 95(25):14932-7. PMID: 9843993. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. |
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