MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain.
| Inventor | Institute |
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| Ron Laskey | University of Cambridge |
| SKU: | 151766 |
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| Product description: | MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal. |
| Alternate name: | Minichromosome Maintenance Complex Component 5; P1-CDC46; CDC46; Minichromosome Maintenance Deficient 5 (Cell Division Cycle 46); EC 3.6.4.12 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | His-tagged human Mcm5 (amino acids 367582) |
| Cat. #: | 151766 |
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| Provenance and Ownership: | The Anti-MCM5 [A2.10A12.A2.B11.A10] is owned by Cancer Research UK. CancerTools supplies the Anti-MCM5 [A2.10A12.A2.B11.A10] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-MCM5 [A2.10A12.A2.B11.A10] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; WB |
| Target: | Mini Chromosome Maintenance protein5 (MCM5) |
| Reactivity: | Human |
| Clone: | A2.10A12.A2.B11.A10 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
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