| Inventor | Institute |
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| Mike Horton | Queen Mary University of London |
| SKU: | 151057 |
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| Product description: | Monoclonal antibody capable of detecting osteoclasts and macrophages. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | A cell suspension containing osteoclasts from osteoclastomas. |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151057 |
|---|---|
| Provenance and Ownership: | The Anti-Macrophage marker 0.555555555556 is owned by Cancer Research UK. CancerTools supplies the Anti-Macrophage marker 0.555555555556 under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Macrophage marker 0.555555555556 directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Immunology |
| Application: | IHC |
| Target: | Macrophage marker |
| Reactivity: | Human |
| Clone: | 0.555555556 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Macrophages are comprised of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. Functions of macrophages include non-specific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors. They also assist with the killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of enzymes and regulatory molecules. Antibody 5/9 may be used as a macrophage cell marker. The antigen is present in osteoclasts and 5/9 may be useful for the identification of osteoclasts in tissues relevant to developmental pathobiology. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. |
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